Surveillance study finds high levels of drug-resistant gonorrhea in Cambodia
Data from 10 sentinel sites in Cambodia show a high prevalence of ceftriaxone-resistant and multidrug- and extensively drug-resistant (XDR) gonorrhea, researchers reported yesterday in JAC-Antimicrobial Resistance.
To investigate Neisseria gonorrhoeae levels in Cambodia, which has been linked to cases of ceftriaxone-resistant gonorrhea in France and Australia, researchers with the World Health Organization (WHO) Enhanced Gonococcal Antimicrobial Surveillance Program (EGASP) analyzed urethral swabs of 437 male patients who presented at the 10 sites with urethral discharge from January 2022 to June 2023. Of those men, 306 had positive N gonorrhoeae cultures, antimicrobial resistance (AMR) test results, and complete epidemiologic data.
Findings of 'grave concern'
Resistance ceftriaxone, cefixime, azithromycin, and ciprofloxacin was 15.4%, 43.1%, 14.4%, 97.1%, respectively. Nineteen (6.2%) of isolates collected from 7 of the 10 sentinel sites were resistant to all four antibiotics and categorized as XDR. Furthermore, 18 of the 19 XDR isolates displayed high-level resistance to azithromycin.
The most frequently reported treatment was the nationally recommended dual therapy of cefixime plus azithromycin, which was used in 65.4% of cases. The rest were treated with ceftriaxone plus azithromycin. Of the 30 patients who received a test of cure, 11 (36.6%) were still N gonorrhoeae–positive.
The authors of the study note that the prevalence of resistance to ceftriaxone, cefixime, and azithromycin all exceeded the 5% AMR level used by the WHO and other public health agencies to indicate when the recommended first-line treatment should be changed. They say the findings are of "grave concern" both for Cambodia and from an international perspective.
"This necessitates expanded N. gonorrhoeae AMR surveillance, revision of the nationally recommended gonorrhoea treatment, mandatory test of cure, enhanced sexual contact notification, and ultimately novel antimicrobials for the treatment of gonorrhoea," they wrote.
https://www.cidrap.umn.edu/antimicrobia ... a-cambodia
high levels of drug-resistant gonorrhea in Cambodia
- Bong Burgundy
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high levels of drug-resistant gonorrhea in Cambodia
Bringing the news. You stay classy, nas, Cambodia.
What is a sentinel site in the study of Cupid's measles?
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A guy round here got it recently. Got his shots and week later was with the same brass and had to make another trip to a not best pleased health worker.
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